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Holz, David

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Holz, David

Dr.-Ing. David Holz

David Holz
David Holz
postdoctoral researcher

Department of Mechanical Engineering
Institute of Applied Dynamics (LTD, Prof. Leyendecker)

Room: Room 01.016
Immerwahrstrasse 1
91058 Erlangen
Germany
  • Phone number: +49 9131 85-61009
  • Fax number: +49 9131 85-61011
  • Email: david.holz@fau.de
  • Website: https://www.ltd.tf.fau.de/david-holz

  • 2013 B.Eng. in Mechanical Engineering, DHBW Ravensburg – Campus Friedrichshafen
  • 2013 – 2015 Development Engineer, Mechatronic Systems, Brose Fahrzeugteile GmbH & Co. KG, Würzburg, Germany
  • 2017 M.Sc. in Computational Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg
  • 2018 – 2023  doctoral candidate, Institute of Applied Dynamics, Friedrich-Alexander-Universität Erlangen-Nürnberg
  • 2024 – postdoctoral researcher, Institute of Applied Dynamics, Friedrich-Alexander-Universität Erlangen-Nürnberg

theses

2017

  • Holz D.:
    Computing fibre orientation for a finite element model of a rat heart (Master thesis, 2017)

 

reviewed journal publications

2023

  • Holz D., Martonová D., Schaller E., Duong MT., Alkassar M., Weyand M., Leyendecker S.:
    Transmural fibre orientations based on Laplace-Dirichlet-Rule-Based-Methods and their influence on human heart simulations
    In: Journal of Biomechanics (2023), Article No.: 111643
    ISSN: 0021-9290
    DOI: 10.1016/j.jbiomech.2023.111643
  • Martonová D., Holz D., Duong MT., Leyendecker S.:
    Smoothed finite element methods in simulation of active contraction of myocardial tissue samples
    In: Journal of Biomechanics (2023)
    ISSN: 0021-9290
    DOI: 10.1016/j.jbiomech.2023.111691

2022

  • Martonová D., Holz D., Brackenhammer D., Weyand M., Leyendecker S., Alkassar M.:
    Support Pressure Acting on the Epicardial Surface of a Rat Left Ventricle — A Computational Study
    In: Frontiers in Cardiovascular Medicine 9 (2022)
    ISSN: 2297-055X
    DOI: 10.3389/fcvm.2022.850274
  • Martonová D., Holz D., Seufert J., Duong MT., Alkassar M., Leyendecker S.:
    Comparison of stress and stress–strain approaches for the active contraction in a rat cardiac cycle model
    In: Journal of Biomechanics 134 (2022), Article No.: 110980
    ISSN: 0021-9290
    DOI: 10.1016/j.jbiomech.2022.110980

2021

  • Holz D., Duong MT., Martonová D., Alkassar M., Leyendecker S.:
    A Transmural Path Model Improves the Definition of the Orthotropic Tissue Structure in Heart Simulations
    In: Journal of Biomechanical Engineering-Transactions of the Asme 144 (2021), p. 031002 (10 pages)
    ISSN: 0148-0731
    DOI: 10.1115/1.4052219
  • Martonová D., Alkassar M., Seufert J., Holz D., Duong MT., Reischl B., Friedrich O., Leyendecker S.:
    Passive mechanical properties in healthy and infarcted rat left ventricle characterised via a mixture model
    In: Journal of the Mechanical Behavior of Biomedical Materials 119 (2021), Article No.: 104430
    ISSN: 1751-6161
    DOI: 10.1016/j.jmbbm.2021.104430
  • Martonová D., Holz D., Duong MT., Leyendecker S.:
    Towards the simulation of active cardiac mechanics using a smoothed finite element method
    In: Journal of Biomechanics 115 (2021), p. 110153
    ISSN: 0021-9290
    DOI: 10.1016/j.jbiomech.2020.110153

2019

  • Duong MT., Holz D., Alkassar M., Dittrich S., Leyendecker S.:
    Interaction of the mechano-electrical feedback with passive mechanical models on a 3D rat left ventricle: a computational study
    In: Frontiers in Physiology 10 (2019), p. 10-41
    ISSN: 1664-042X
    DOI: 10.3389/fphys.2019.01041
    URL: https://www.frontiersin.org/articles/10.3389/fphys.2019.01041/abstract

 

conferences and proceedings

2023

  • Martonová D., Holz D., Duong MT., Leyendecker S.:
    Smoothed finite element methods in modelling and simulation of active cardiac contraction
    conference, 18th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (Paris, 2023-05-03 - 2023-05-05)

2022

  • Holz D., Martonová D., Schaller E., Duong MT., Alkassar M., Leyendecker S.:
    The influence of the orthotropic tissue in an electromechanical heart model
    conference, 27th Congress of the European Society of Biomechanics (Porto, 2022-06-26 - 2022-06-29)

2021

  • Holz D., Duong MT., Martonová D., Alkassar M., Leyendecker S.:
    Discontinuous Galerkin-based approach to define orthotropic tissue structure in computational heart models
    conference, International Conference on Computational Biomechanics (Paris, 2021-09-20 - 2021-09-21)
  • Martonová D., Alkassar M., Seufert J., Holz D., Duong MT., Reischl B., Friedrich O., Leyendecker S.:
    Characterisation of passive mechanical properties in healthy and infarcted rat myocardium
    conference, GAMM Annual Meeting (Kassel, 2021-03-15 - 2021-03-19)
  • Martonová D., Alkassar M., Seufert J., Holz D., Duong MT., Reischl B., Friedrich O., Leyendecker S.:
    Influence of passive mechanical properties in healthy and infarcted rat myocardium on the cardiac cycle
    GAMM Annual Meeting (Kassel, 2021-03-15 - 2021-03-19)
    In: Proc. Appl. Math. Mech. (PAMM) 2021
    DOI: 10.1002/pamm.202100054

2019

  • Holz D., Duong MT., Alkassar M., Dittrich S., Leyendecker S.:
    Computational study of ventricular fibrillation by considering a strongly coupled electromechanical rat heart model
    GAMM Annual Meeting (Vienna, 2019-02-18 - 2019-02-22)
    In: Procc. App. Math. Mech. (PAMM) 2019
    DOI: 10.1002/pamm.201900227
  • Holz D., Duong MT., Kim M., Alkassar M., Dittrich S., Leyendecker S.:
    Nonlinear fibre distribution in a finite element model of a human left ventricle for sparse and non-constant data sets
    8th GACM Colloquium on Computational Mechanics (Kassel, 2019-08-28 - 2019-08-30)
    In: Proceedings of the 8th GACM Colloquium on Computational Mechanics 2019
  • Holz D., Duong MT., Kim M., Alkassar M., Dittrich S., Leyendecker S.:
    Nonlinear fibre distribution in cardiac modelling
    25th Congress of the European Society of Biomechanics (Vienna, 2019-07-07 - 2019-09-10)
  • Holz D., Duong MT., Martonová D., Alkassar M., Dittrich S., Leyendecker S.:
    Möglichkeiten und Perspektiven der Modellierung und Simulation
    Wissenschaftliche Jahrestagung der Deutschen Gesellschaft für Thorax-, Herz- und Gefäßchirurgie (Wiesbaden, 2019-02-16 - 2019-02-19)

2018

  • Duong MT., Holz D., Ach T., Binnewitt SV., Stegmann H., Dittrich S., Alkassar M., Leyendecker S.:
    Simulation of cardiac electromechanics of a rat left ventricle
    GAMM Annual Meeting (Munich, 2018-03-19 - 2018-03-23)
    In: Proc. Appl. Math. Mech. (PAMM) 2018
    DOI: 10.1002/pamm.201800326
  • Holz D., Duong MT., Alkassar M., Dittrich S., Leyendecker S.:
    Computational model of a rat left ventricle
    8th Summer School on Biomechanics, from Protein to Tissue to Organ: Modeling and Computation (Graz, 2018-09-03 - 2018-09-07)

2017

  • Duong MT., Wenger T., Herrnböck L., Ach T., Holz D., Kreipp A., Binnewitt SV., Stegmann H., Dittrich S., Alkassar M., Leyendecker S.:
    Modelling cardiac mechanics and electrophysiology of a rat left ventricle: A case study.
    International Conference on Biomedical Technology (Hannover, 2017-11-06 - 2017-11-08)

 

further publications

 

  • Establishment of a heart support system as a contractile membrane based on the pericardium

    (Third Party Funds Single)

    Term: 2016-05-01 - 2022-07-15
    Funding source: Stiftungen
    Abstract

    This projectcontains the establishment of a heart support system as a contractile membrane based on the pericardium to minimize theconsequences of severe heart disease and to maintain proper cardiacfunction. The project is a research cooperation between the Institute ofApplied Dynamics and the Pediatric Cardiology at the Friedrich-Alexander-Universität Erlangen-Nürnberg and is funded by the Klaus Tschira Foundation.

    The project includes the study ofcardiac function under pathological and normal conditions by developing computer models of the heart, which are validated with experimental data ofpediatric cardiology of the University of Erlangen Nuremberg. The clinicalmeasurements and experimental data, as well as the simulation model are basedon rat hearts. Subsequently, a cardiac support system based on a membrane is to be designed to improve or at least maintain heart function under pathological conditions.

    In particular at the Institute of Applied Dynamics, we are focusing on the development of theunderlying computational heart model including the anatomy, morphology,electrophysiology and also the fluid-structure interaction to be able to buildup the optimized heart support system but also to better understand thefunction of the heart and thus to predict or early detect cardiac dysfunctions andbring new treatments to the clinic. 

    →More information
Institute of Applied Dynamics
Friedrich-Alexander-Universität Erlangen-Nürnberg

Immerwahrstrasse 1
91058 Erlangen
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